Which statement about the prevalence of FOP is TRUE?

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by the abnormal development of bone in muscles, tendons, and other connective tissues. The prevalence of FOP is notably low, estimated to affect approximately 1 in 1,500,000 to 1 in 2,000,000 people, which aligns with the statement that classifies it as ultra-rare. This rarity is a key factor that healthcare professionals need to understand when encountering cases that may present symptoms suggestive of FOP.

The statistics highlighting its ultra-rare status emphasize the need for increased awareness and knowledge among healthcare providers since such conditions often lead to misdiagnosis or a lack of proper management due to their obscurity. In contrast, the other statements are misleading as they either overstate the prevalence or imply a level of understanding and available diagnostic criteria that do not reflect the true nature of FOP, which can be complex and challenging to diagnose.