Which statement about the diagnosis of FOP is TRUE?

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder characterized by the abnormal formation of bone in muscles, tendons, and ligaments, leading to progressive immobility. The rarity of the disease results in a lack of widespread familiarity among healthcare providers, which can contribute to frequent misdiagnoses.

The statement that misdiagnosis of FOP is common due in part to the rarity of the disease reflects the reality that many clinicians may not encounter this condition often enough to recognize its distinctive features promptly. FOP has specific clinical signs, such as congenital deformities of the big toes and episodes of soft tissue swelling. However, these signs can easily be mistaken for other conditions, particularly in the absence of a formal diagnosis.

Additionally, without formal diagnostic criteria, the subtleties of FOP can be overlooked, especially in emergency settings or among practitioners not specializing in rare diseases. Hence, awareness and education about FOP are critical, as misdiagnosis can lead to complications, including unnecessary surgical interventions, which can further worsen the condition.