What is the risk of performing intramuscular injections in patients with FOP?

Patients with Fibrodysplasia Ossificans Progressiva (FOP) are at a significantly increased risk for heterotopic ossification, which is the abnormal growth of bone in soft tissues. This condition can be triggered by trauma or injury, and intramuscular injections can introduce trauma to the muscle tissue. Given that FOP is characterized by episodes of abnormal bone formation, intramuscular injections can provoke a reaction leading to the formation of bone in muscle, which may result in permanent and disabling complications.

Additionally, the risk associated with intramuscular injections in a patient with FOP is particularly concerning because the ossification can limit mobility and lead to serious functional impairments. Therefore, the primary danger of administering intramuscular injections in these patients is not just temporary discomfort but the potential for irreversible bone growth that can severely affect their quality of life. This understanding emphasizes the critical nature of patient history and condition assessments before administrative actions such as injections.