What is the long-term prognosis for individuals diagnosed with FOP?

Individuals diagnosed with Fibrodysplasia Ossificans Progressiva (FOP) typically experience a progressive decline in mobility and function over time. FOP is a rare genetic disorder characterized by the abnormal formation of bone in muscles, tendons, and other connective tissues, often in response to injury or stress. This ossification process leads to a gradual and irreversible restriction of movement, causing affected individuals to become more disabled as they age.

The progressive nature of FOP means that, rather than seeing improvement in mobility, individuals often encounter increased limitations and joint stiffness. The condition can also lead to life-threatening complications, such as respiratory issues due to thoracic insufficiency caused by ossification around the rib cage.

While some patients may maintain a degree of function for certain periods, the long-term prognosis remains one of functional decline rather than improvement. The other options suggest scenarios that do not accurately represent the trajectory of this disorder; complete resolution of symptoms is not possible in FOP, and while many individuals may have normal lifespans, they often face significant mobility challenges as the disease progresses.