What is a hallmark feature of fibrodysplasia ossificans progressiva?

The hallmark feature of fibrodysplasia ossificans progressiva (FOP) is indeed a loss of mobility. FOP is a rare genetic condition characterized by the abnormal formation of bone in muscles, tendons, and other connective tissues, a process known as heterotopic ossification. This condition typically progresses over time, leading to a gradual restriction of movement. As new bone forms in areas where it should not, patients experience increasing stiffness and immobility, particularly affecting joints and limbs.

Loss of mobility is a significant concern for individuals with FOP, resulting from the ossified tissues limiting their range of motion and ability to perform everyday activities. The condition can lead to severe disability, and managing mobility becomes a central focus of care as the disease progresses.

Other options provide relevant information but do not encapsulate the primary characteristic of FOP as effectively. For example, while increased severity of muscle trauma may occur due to an increased risk of flare-ups or injuries, it is not as defining of the condition as the progressive loss of mobility. Heightened risk of intramuscular complications can be more related to the development of ossification and muscle behavior after injury, but still lacks the clarity offered by the primary mobility focus. Growth spurts